Assessment of the Effects of Methanol Leaf Extract of Clerodendrum violaceum on the Liver of Mice

Effects of methanol leaf extract Clerodendrum violaceum on liver function indices Swiss mice was evaluated. Six groups (A-F) ten each were used. Groups B-F administered 31.25, 62.5, 125, 250, 500 mg/kg body weight violaceum, respectively. Group A received 5% DMSO (control). Five animals in group sacrificed after 14 days administration; the remaining 28 administration. Blood collected for analyses, livers and weighed. Some samples homogenized some preserved 10% formalin histopathological examination. After days, there significant increase (p < 0.05) total conjugated bilirubin reduction albumin protein at higher doses. Activities ALP γ-GT serum significantly elevated all doses while ALT activity only lower Liver AST also reduced highest dose serum. but tissue inflamed with progressive degeneration day 28. Results showed that C. adversely affected normal architecture, synthetic secretory functions high